Endocrine Abstracts

Background: Androgen excess and metabolic abnormality largely contribute to the pathogenesis of PCOS, which primarily precipitates ovarian dysfunction and infertility in reproductive-age women. Impaired mitochondrial function and epigenetic alteration have been linked to the development of PCOS. However, the therapeutic potential of histone deacetylase (HDAC) inhibition on ovarian mitochondrial dysfunction is unclear, especially in PCOS is unclear. Herein, the...